What Is the Best Treatment for Recurrent Implantation Failure (RIF) in Women? Dr pegah keramati

One of the major challenges in infertility treatment is Recurrent Implantation Failure (RIF). This condition occurs when high-quality embryos are transferred to the uterus multiple times but pregnancy does not happen. Many couples experience anxiety and disappointment after several unsuccessful IVF cycles. The good news is that with accurate evaluation and proper treatment, success is still possible.

In this article, we’ll explore the best treatment options for recurrent implantation failure from the perspective of Dr. Pegah Keramati.

What is Recurrent Implantation Failure?

In medical terms, if pregnancy does not occur after two to three transfers of good-quality embryos (through IVF or ICSI), the condition is referred to as Recurrent Implantation Failure. It indicates a failure in the proper interaction between the embryo and the uterine environment.

Main Causes of Recurrent Implantation Failure:

🔹 Uterine abnormalities such as polyps, fibroids, adhesions, or abnormal uterine shape
🔹 Genetic abnormalities in the embryos or parents
🔹 Immune system or blood clotting disorders in the mother
🔹 Poor endometrial receptivity
🔹 Hormonal imbalances or chronic endometrial inflammation

Best Treatment Options for RIF According to Dr. Pegah Keramati:

✅ Detailed Uterine Evaluation via Hysteroscopy:
A complete visual examination of the uterus helps detect hidden issues like fibroids, polyps, or adhesions.

✅ Genetic Screening of Embryos (PGT-A):
Preimplantation genetic testing allows for the selection of chromosomally normal embryos, improving chances of success.

✅ Treatment of Immune and Coagulation Disorders:
Specialized tests (like antiphospholipid antibodies, ANA, thrombophilia panels) can reveal underlying issues. Treatment may involve aspirin, heparin, or immunomodulatory medications.

✅ Synchronizing Endometrium and Embryo:
Using advanced tools like the ERA test (Endometrial Receptivity Analysis), Dr. Keramati determines the optimal timing for embryo transfer.

✅ Adjunct Therapies to Improve Implantation:
Options such as intrauterine PRP (Platelet-Rich Plasma), cytokine therapy, and targeted antibiotic treatments can enhance endometrial receptivity.

✅ Optimizing Pre- and Post-Transfer Care:
Customized medication protocols, lifestyle adjustments, proper nutrition, and stress reduction all contribute to treatment success.

Recurrent implantation failure is not the end — it’s a call for deeper investigation and personalized treatment. With patience, knowledge, and planning, many cases can turn into successful pregnancies.